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Accutane Journey Testimonial

Skin care


Too many women become pregnant while taking drug that can harm a fetus

Landon tuggles says her doctor prescribed Accutane without adequate warnings 1:16346 comments

Doctors stress that a powerful drug prescribed to fight acne needs to be taken under strict guidelines to prevent serious harm to a fetus, as a new study commissioned by Health Canada points to many failures in preventing pregnancy.  

Isotretinoin was commonly sold as Accutane when it entered the market in Canada in 1983 to treat severe acne, which can cause scarring such as pockmarks. The medication is now available as Accutane Roche and in several generic forms. Since the drug can cause damage to the head, face, heart, central nervous system and limbs of a fetus, the prescribing information in Canada requires written consent from the patient, two negative pregnancy tests before treatment and the use of two reliable methods of birth control. These conditions apply to prescriptions dispensed to women of child-bearing age.

The study, published in Monday's issue of the Canadian Medical Association Journal, suggests the pregnancy prevention program is not effective, with between 30 per cent to 50 per cent of women taking the drug not complying.

"The program is probably half as effective as it should be," said the study's lead author, Dr. David Henry, a senior scientist at the Institute for Clinical Evaluative Sciences and a professor at the University of Toronto.

Henry and his team used hospital and vital statistical data to study 59,271 female patients aged 12 to 48 in British Columbia, Saskatchewan, Manitoba and Ontario for about 15 years. Over that time, nearly 1,473 pregnancies, about 100 a year, occurred during the vulnerable period during and after treatment with isotretinoin. The risky period includes any time during the 42 weeks of a pregnancy. 

Pregnancy losses

Of these pregnancies, 1,331 or 90 per cent weren't completed. The majority, 70 per cent, were medically terminated because the patient and health-care provider were worried about the risk to the fetus or had ultrasounds showing abnormalities. Another 20 per cent of the pregnancies were lost spontaneously. 

Of the remaining 10 per cent of live births, a total of 11 babies or nine per cent were born with abnormalities, which amounts to one or two children each year. Researchers don't know the severity of the abnormalities or if use of the acne drug directly caused the congenital abnormalities. 

Henry said he believes greater familiarity with the effective drug, which is generally well tolerated, has led to its use in less severe cases of acne.

"It should be reserved for more severe cases [of acne] because that just cuts down the number of women of childbearing age who are going to be exposed to the drug," Henry recommended. 

It's estimated the average age of isotretinoin users in Canada is 24.

"Conjecture is that physicians who are coming through these days didn't get the same scary messages that we did," Henry said.

Dr. Shannon Humphrey is a dermatologist in Vancouver and a professor in the dermatology department at the University of British Columbia. She is a spokeswoman for the Acne and Rosacea Society of Canada and wasn't involved in the study.

Humphrey said for many of her patients, the benefits of isotretinoin outweigh the risks.

"As physicians, we should not become complacent," Humphrey said. "There are absolutely patients who have moderate acne, who've tried other alternatives and who are suffering, who have anxiety or depression or are not engaging in their daily life because of the stigma of acne. And for that patient, as long as they can understand the side-effect profile, as long as they can engage with the pregnancy prevention recommendations very stringently, that may very well be an ideal candidate for this medication."

Outside of birth defects, the majority of side-effects from the drug include dry skin and sensitivity, she said. Doctors also monitor blood work to check cholesterol levels and liver function after prescribing the drug, which is generally taken for three to four months.

Now that isotretinoin is generic, there's less emphasis on education about it for specialists, said Humphrey, who welcomes greater awareness.

Henry stressed that physicians need to be reminded of their obligations to comply with the prescribing guidance for the drug.

Robyn Sheremeta is a university student in Toronto who describes her acne as moderate and persistent. More than a year ago when she was 22, Sheremeta booked an appointment with a dermatologist at her family's hometown in Edmonton. She thought she'd be prescribed antibiotics or another oral drug to "dull the acne."

Sheremeta was already taking birth control pills. The dermatologist prescribed her a year's supply of a different kind of birth control pill and mentioned using a second method when having sex, she said.

"There was zero monitoring,"  Sheremeta recalled. "I didn't do a single pregnancy test, no blood work. I was given a four-month set of [isotretinoin] pills." 

Sheremeta completed the treatment, the acne disappeared and she now feels it is back to mild to moderate. 

Both Henry and Humphrey also said pharmacists can act as a second line of defence when dispensing the drug. 

One of the limitations of the study was it only captured prescriptions, including for birth control, from provincial drug benefit insurance programs.

About one-quarter to one-third of women in the study filled birth control prescriptions, which was about the same as before they started the acne treatment.

Studies in Europe also suggest that changing contraceptive behaviour among isotretinoin users is difficult, the researchers said.

A spokesman for Health Canada said pregnancy rates for women taking the drug in other international jurisdictions are similar to those reported in Canada. The department is reviewing the results of the study. 
 

Physicians are expected to follow a manufacturer's risk management program if one is in place, as recommended by Health Canada, said a spokeswoman for the College of Physicians and Surgeons of Ontario.

Doctors are expected to practise competently and to maintain the applicable standard of practice when prescribing drugs, including when prescribing isotretinoin products, the college said. 

The study was conducted by the Canadian Network for Observational Drug Effect Studies, or CNODES, which is funded by the Canadian Institutes of Health Research (CIHR).

Indian-Generics.com Reviews

Aanvullende informatie

REVIEWS

Indian-generics.com Review – A Web Store with No Customer Reviews To Back-Up Promises

September 16, 2018

Indian-generics.com was an online pharmacy that offered erectile dysfunction medicines to their customers among other medications. Based on its domain name, we assumed that this e-store was Indian based. We cannot confirm this though as its location was not disclosed on the website along with its operation date.

Indian-generics.com offered different medications such as drugs for allergy, bacterial infection, convulsant, depression, fungal infection, viral infection, antibiotics, asthma, and gout. They also offered drugs for cancer, cardiovascular, inflammatory drugs, lung diseases, migraines, muscle relaxant, thyroid, pain medications, skin care, erectile dysfunction, and weight loss.

For erectile dysfunction, their bestsellers were generic Viagra for $1.08 per tablet, generic Cialis for $1.17 per tablet, generic Levitra for $2.22 per tablet, and generic Cialis Soft for $1.75 per tablet. Their branded Levitra for $10.25 was also a bestseller as well as Kamagra for $2.94 per tablet. Branded Cialis was also sold for $9.83 per pill while branded Viagra was sold for $5.08 per tablet. For other bestsellers, they also had Zithromax, Clomid, Propecia, Lasix, and Tamiflu.

Ordering from Indian-generics.com was easy and practical as they offered two shipping methods that customers can choose from. They offered Trackable Courier Service for $50 and International Unregistered Mail for $10. Trackable Courier Service takes up to 9 days for the delivery to be completed and up to 21 days for Registered Mail. For payment, this e-dispensary accepted credit card, electronic check, and bank wire transfer.

For queries and concerns, Indian-generics.com provided 1646 205 2937 or 866 417 5821 as their contact number. They also had a live chat support system during their operation while their contact us page was also available for customers who wanted to reach them thru email.

Indian-generics.com Reviews

Finding customer reviews is one of the ways of determining a web store’s reputation. We are disappointed to find no third-party reviews for Indian Generics, hence we settled with the reviews found on their testimonial page.

Indian-generics

Most of the testimonials we found on the testimonial page of Indian-generics.com were one-liners. One customer said he received good help from the support team and another said he never had to worry about side effects. One user also claimed that Indian-generics.com was a wonderful website and he never had an issue ordering from them. Caril, another customer said that the service he received from this e-store exceeded his expectation. Lastly, Muddy added that the customer service of Indian-generics was beyond excellent.

The testimonials that we found focused on three things – effective drugs, excellent service, and quick service. These are good reviews but because these are from the testimonial page of Indian-generics.com, we are bound not to consider this feedback as reliable. The risk of them being fake reviews is too high.

Indian-generics.com Reviews 2018

Indian-generics.com has been down for a few months now and after exhausting our resources, we are unable to find customer reviews shared this year. For now, since the only reviews found were from their own site, we can say that this e-store was not able to back up their claims, as there was no customer review to attest to it.

Indian-generics.com Coupon Codes

Indian-generics

Most internet drugstores take advantage of coupon codes as a way to win new customers. It is their way of ensuring that possible new customers will consider them while old customers will consider coming back.

During their run, Indian-generics.com did not release any store coupon codes. What they offered to their customers were free pills in all orders. This means that all orders come with free sample pills from Indian-generics.com.

Conclusion

Indian-generics.com was an online pharmacy that offered generic medicines to their worldwide customers. Their pricing was a bit high as compared to other online pharmacies especially their branded medication offers.

We noticed that most of their ED medications were sold for more than $2 per pill when most Indian generic ED drugs are sold for less than $2 per tablet. Their branded Cialis for $9.83 and branded Levitra for $10.25 are of the same prices as those sold in local pharmacies. During its operation which was between 2008 to 2017, we can say that their pricing was a bit high.

We appreciate the fact that they offered different options in terms of shipping and payment. We also find their extensive list of medicines a good one.

What we find doubtful about Indian-generics.com were their on-site customer reviews. They had some customer reviews that can be found on their own testimonial page. All reviews were short and sweet. As an online consumer, we believe that there is always a room for improvement in terms of service and products delivered but Indian-generics.com seems to have perfected it based on the testimonials we found. Because of this, we strongly believe that the reviews were compromised and were probably owned or written by the operator of this e-store. It was even sadder to be unable to find customer reviews from reliable third-party review sites.

Lastly, without personal information such as location, office address, and history or background, we have to consider Indian-generics.com as not a reliable online pharmacy that operated a few years ago.